Aryl derivatives secondary alkylamines

Catalytic amounts of Co(OAc)2 or Mn(OAc)2 in combination with ferf-butyl hydrogen peroxide (1.2 equiv.) as oxidant proved to be effective for amination of benzoxazoles, benzothiazoles, and 2-phenyl-1,3,4-oxadiazole [95]. It is worth noting that in amination of benzoxazoles with secondary aliphatic amines the cobalt catalyst provides better results, while the manganese catalyst is more effective for a similar reaction with primary alkylamines and ammonia. Also the reactions of benzoxazoles with secondary aliphatic amines or formamides have been performed successfully with Cu(OAc)2 (20 mol.%) and oxygen as oxidant [96]. Other azoles do not react with primary alkylamines in the presence of this oxidant. In contrast, when FeCls was used in 0.25-1 equiv. amounts, amination of benzoxazoles and 2-aryl-1,3,4-oxadiazoles (with the exception of their nitro derivatives) proved to... 

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