Artificial planar macrocycles - phthalocyanines and other cyclic systems

Distil ca. 3 mL pyrrole from a 25 mL round-bottomed flask, collecting the colourless fraction that boils between 128 and 131 °C. If required this can be stored in a freezer for several days before use. 

2 Artificial Planar Macrocycles - Phthalocyanines and Other Cyclic Systems 

As is the case with so many chemical discoveries, phthalocyanines were first obtained through the accidental addition of a catalyst or templating agent to a 

Perhaps of greater benefit is the use of phthalocyanines in photodynamic therapy [8]. This treatment utilizes the ability of phthalocyanine complexes, when irradiated, to generate cytotoxic and antiviral species, such as hydroxyl radicals and singlet oxygen, that in turn effect the tissue surrounding the complexes. The greatest use of this form of therapy is with skin-related conditions, as the incident light does not have to penetrate too far into the tissue to activate the complexes. 

Copper (II) bromide (anhydrous) l,5-Diazabicyclo[4.3.0]non-5-ene (DBN) 2-Methoxyethyl ether (diglyme) 

---

ARTIFICIAL PLANAR MACROCYCLES - PHTHALOCYANINES AND OTHER CYCLIC SYSTEMS... 

---