Artificial Enzyme Mimics

Material Conversion - Natural and Artificial Enzymes Enzymes perform highly selective and highly efficient molecular conversion based on sophisticated three-dimensional arrangements of amino acids. Artificial enzyme mimics can be constructed using cyclodextrins and Hpid bilayer membranes. 

Catalytic antibodies are, so far, among the most efficient artificial enzyme mimics. Although, in general, they do not exhibit enzyme-like rates, mechanistic and structural studies concerning catalysis offer deeper insight in the mechanism of action of natural enzymes. 

Raynal M, et al. Supramolecular catalysis. Part 2 artificial enzyme mimics. Chem Soc Rev 2014 43 1734-87. 

Using modified P-cyclodextrine 23, Bender et al. report a ji-cyclodextrine based artificial enzyme mimic with a catalytic triad that has catalyzed hydrolysis rates of 10 -10 faster for norbomyl cinnamate ester [21], They show that 1 mol of 23 could be used in the hydrolysis of more than 10 mol of substrate, which proves a multiple turnover of the catalyst. The proposed mechanism is shown in Fig. 7.1. This mechanism was evaluated and questioned by Zimmerman [22],... 

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