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Artifacts cytotoxicity

The lithistid sponge Aciculites orientalis contains three cyclic peptides, aciculitins A-C (130-132), that are identical except for homologous lipid residues [149]. The aciculitins consist of a bicychc peptide that contains an unusual histidino-tyrosine bridge. Attached to the bicyclic portion are Ci3-Ci5-dihydroxy-4,6-dienoic acids bearing D-lyxose at the C-3 position. The paper also reports the structures of the two artifacts aciculitamides A and B obtained earlier from the same sponge. The aciculitins inhibited the growth of Candida albicans and are cytotoxic toward the HCT-116 cell line. [Pg.1214]

Polycarpine dihydrochloride is a dimer alkaloid made up of two immonium salts connected by a disulfide bridge. It was isolated from the spedes Polycarpa clavata harvested in Australia. This orange, water-soluble pigment was accompanied by several monomer forms but it has been shown that these are artifacts. This atypical alkaloid is cytotoxic to HCT-116 human colon cells with an IC50 of 0.9 [xgml . ... [Pg.1695]

See other pages where Artifacts cytotoxicity is mentioned: [Pg.141]    [Pg.186]    [Pg.687]    [Pg.836]    [Pg.84]    [Pg.339]    [Pg.55]    [Pg.229]    [Pg.110]    [Pg.112]    [Pg.117]    [Pg.224]    [Pg.286]    [Pg.233]    [Pg.398]    [Pg.222]    [Pg.301]    [Pg.100]    [Pg.544]    [Pg.545]    [Pg.25]    [Pg.104]    [Pg.386]    [Pg.283]    [Pg.1665]   
See also in sourсe #XX -- [ Pg.230 ]



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