Arthritis, rheumatoid biochemistry

Kearney, P.L., Bhatia, M., Jones, N.G., Yuan, L., Glascock, M.C., Catchings, K.L., Yamada, M. and Thompson, P.R. (2005) Kinetic characterization of protein arginine deiminase 4 a transcriptional corepressor implicated in the onset and progression of rheumatoid arthritis. Biochemistry, 44, 10570-10582. 

Considering that tens of millions of people suffer from rheumatoid arthritis (1) and that gold-based anti-arthritis pharmaceuticals have been proven to induce remission of this frequently crippling disease (2), it is surprising how little is known about gold biochemistry... 

Fig. 21.5 Representative MALDI-TOF MS spectra (positive ion mode) of an organic extract of synovial fluid (a) and plasma (b) from a selected patient suffering from rheumatoid arthritis. Peaks are labeled according to their m/z ratio and characteristic DHB matrix peaks are labeled with asterisks. Reprinted with modifications from Clinical Biochemistry, 38, Fuchs et al.. The phosphatidylcholine/lysophosphatidylcholine ratio in human plasma is an indicator of the severity of rheumatoid arthritis investigations by P NMR and MALDI-TOF MS, 925-933, Copyright (2005) with permission from Elsevier...

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