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Artemisinin semi-synthetic derivatives

In addition to artemisinin, other synthetic trioxanes and endoperoxides (fenozan BO-7 4 and arteflene 5 " ) have enjoyed some success arteflene reached Phase II pre-clinical trials. More recently, Vennerstrom and coworkers have reported on the outstanding antimalarial properties of several 1,2,4-trioxolanes, one of which, OZ 277 (6), has entered clinical trials in man . These exciting, easily prepared drugs will be discussed in detail later in this chapter. In order to determine the parasiticidal action of this class of antimalarial, many research groups have focused their efforts on artemisinin and its semi-synthetic derivatives (artemether, arteether and artesunate Ic, Id and le), and this is the point where our discussion will begin. [Pg.1282]

G3 factor, 199, 201, 202 mechanisms, 1309, 1310 NMR spectroscopy, 710 OZ 277 drug candidate, 1317, 1319, 1331 Plasmodium falciparum resistance, 608 synthetic, 1282, 1317-31 antimalarial activities, 1332 semi-synthetic artemisinin derivatives, 1313-17, 1332... [Pg.1443]

See other pages where Artemisinin semi-synthetic derivatives is mentioned: [Pg.18]    [Pg.1443]    [Pg.909]    [Pg.116]    [Pg.276]    [Pg.243]    [Pg.1279]    [Pg.1281]    [Pg.1313]    [Pg.1320]    [Pg.1279]    [Pg.1281]    [Pg.1313]    [Pg.1320]    [Pg.21]    [Pg.28]    [Pg.55]   
See also in sourсe #XX -- [ Pg.1332 ]



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Artemisinin

Artemisinin derivatives

Artemisinins

Semi-derivative

Semi-synthetics

Synthetic derivatives

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