Artemisinin-naphthoquine

Naphthoquine + artemisinin A new anti-malarial formulation containing a fixed-dose combination of naphthoquine and artemisinin in a 1 2.5 ratio has been assessed in an open study in 28 healthy volunteers who took single oral doses of 350, 700, 1400, or 2100 mg of artemisinin + naphthoquine [18/]. The combination increased the AUC and Cmax of both artemisinin and naphthoquine compared with monotherapy. Food greatly increased the AUC of artemisinin and reduced that of naphthoquine. 

Comparative studies A total of 401 adulf malaria subjecfs were enrolled in a Phase 111, randomised, open-label, mulficenfer study and received either a single dose (four tablets) of artemisinin-naphthoquine (AN) or DHP three to four tablets single daily dose for 3 days [26 ]. The patients were followed up to day 42 for physical examination and thick and thin smears microscopy. Efficacy of the drug was assessed by polymerase chain reaction (PCR). 

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