Artemisinin 11-Hydroxyartemisinin

Artemisinin E. amstelodami Cultures were incubated at 500 mg L 1 Residual artemisinin after 5p-Hydroxyartemisinin 7p- [52]... 

Woerdenbag et al also evaluated the influence of chiral center configurations present in artemisinin (1) structure on the proliferation of Ehrlich ascites tumor (ETA) cells. Compounds 11-hydroxyartemisinin (47) and 11-hydroxy-11-epi-artemisinin (48) (Fig. 4) were synthesized and the... 

Using various derivatives of artemisinic acid, the methodology onthned in Scheme 184 was extended to the synthesis of a nnmber of modified artemisinin-type tetracychc trioxanes. For example, the syntheses of 6,9-desdimethylartemisinin 586a , A-fi-hydroxyartemisinin , and C9-alkylated artemisinin analognes were reported . In some cases it is possible to avoid the lactonization step while preserving the ester fnnctionality and interrnpting the cychzation of aldehyde-peroxyhemiacetals of type 652, at the step of formation of tricyclic 5-hydroxy-1,2,4-trioxane . ... 

Studies on the microbial transformation of artemisitene 27 by Aspergillus niger yielded 11- f-artemisinin 88a, 9/3-hydroxydeoxy-1 l-< /)/-artemisinin 89, and 9/3-hydroxy-l l-< /)/-artemisinin 88b. These metabolites were characterized on the basis of their spectral data <1999P257>. When artemisinin 9a was transformed hy Mucorpolymorphosporus or A. niger, five products were identified as 9/3-hydroxyartemisinin 90, 3/3-hydroxyartemisinin 91, deoxyartemisinin 75b, 3/3-hydroxydeoxyartemisinin 75a, and la-hydroxydeoxyartemisinin 92 <2002JNP1693>. 

Zhan et al. (2002) reported that incubation of artemisinin (283) with C. echinulata and A. niger for 4 days at 28°C resulted in the isolation of two metabolites, lOp hydroxyartemisinin (287a) and Sa-hydroxydeojQ artemisinin (285), respectively. 

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