Aroylaminobenzoic acids

Aryloxamic acids, and aroylaminobenzoic acids Upjohn s aryloxamic acid, lodoxamide (U 42,585 E), (XCIV), is 2500 times more potent intravenously than DSCC f661. being the most potent agent thus far reported. However, this compound is 100-1000 fold less potent orally than intravenously, with inhibition in the PCA procedure obtained with oral doses between 0.1 and 10 mg/kg (g ) Activity has been reported in man following aerosol administration (fi7)- Further details on this series are discussed in the next chapter. 

Japanese workers have explored a series of aroylaminobenzoic acids of which N-5 (XCVI), is about equal to DSCC intravenously and has an oral ED50 of 100-150 mg/kg (7Q). It should be noted, however, that this is... 

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See also in sourсe #XX -- [ ]

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