Aromatic acid amides

AROMATIC ACID AMIDES Aromatic acid amides may be prepared — 

By the action of concentrated ammonia solution upon the appropriate acid chloride, for example  

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Method (1) is most frequently used for aliphatic acid amides, while Methods (2a), (2b) and (zc) are used most frequently for aromatic acid amides. Of the last three methods, the Acid Chloride Method (zb) is the most rapid and certain. The Ester Method (za) is practicable only when the amide is insoluble in water, and even then is often very slow unless the ester itself is appreciabb soluble in the aqueous ammonia solution. 

Amalgamated zinc, 198 see also under Clemmenaen reduction Amides, 361 1074, 1075 see also Aliphatic acid amides and Aromatic acid amides... 

Scheme 20.2 Substituted aromatic nitriles as intermediates for aromatic acids, amides, imines, aldehydes and amines. Elaborated from [82a].

Pyrazinethionhydroxamic acid amide Aminothiazoles Aminothiophenes Aminopyrazoles Aminoisoxazoles Pyrroloazepinones Aminotriazolopyrimidines Aminotetrahydronaphthyridines Aminopyrazolopyridines Aminopyridazinones Aminopyndopyrimidines Amino- 1,3,4-thiadiazoles Aminoimidazoles Sulfonamides Amino sugars N-Aiylbenzamidines Thioamides Benzylamines Aromatic acid amides... 

With aromatic acid amides [Fe(C8H403N)3(bipy)3] 300 159 c. 0.619 Gouy 67S22... 

With acid amides and acid hydrazides With aromatic acid amides [Ni(NH2CO CsH4 0-)2] room 3.57 Gouy tetrahedral coordination suggested 73P4... 

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