Sertraline Aripiprazole

Risperidone Aripiprazole 2D6 > 3A4 2D6, 3A4 Carbamazepine and phenytoin topiramate hypericum (St. John s Wort). Paroxetine, fluoxetine, sertraline (high dose) grapefruit juice 2D6 or 3A4 substrates acting as competitive inhibitors. 

Posey et al., 2008) with these agents have been generally consistent with results for risperidone and suggest that the therapeutic benefits of risperidone are likely shared by other drugs in this class. Placebo-controlled trials in ASD patient populations are in progress for olanzapine, sertraline, and aripiprazole (clinicaltrials.gov). 

Drug-drug interactions SSRIs Aripiprazole had no effects on the pharmacokinetics of escitalopram, fluoxetine, paroxetine, sertraline, or venlafaxine either in healthy subjects ( =63) or in patients with major depressive disorder ( =498) [69. Point estimates for mean plasma concentration ratios indicated no substantial effect of aripiprazole on any antidepressant escitalopram 0.97 (0.91-1.03), fluoxetine 1.18 (1.05-1.32), paroxetine 0.73 (0.60-0.89), sertraline 0.96 (0.89-1.04), or venlafaxine 0.97 (0.89-1.05). 

Metabolism A 6-month, retrospective chart review compared patients on aripiprazole alone to aripiprazole and an SSRI (citalopram, fluoxetine, paroxetine, sertraline, venlafaxine) or aripiprazole and bupropion [92 ]. Only the combination of aripiprazole and an SSRI had statistically significant weight gain, thus it was hypothesised that in the presence of high serotonergic activity, aripiprazole acts as an antagonist at the 5-HT2c receptor. 

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