Ketoconazole Aripiprazole

Concomitant use with potential CYP3A4 inhibitors - During coadministration of ketoconazole with aripiprazole, reduce the aripiprazole dose to one-half of the usual dose. 

Aripiprazole is hepatically metabolized, mainly by two cytochrome P450 enzymes CYP 2D6 and CYP 3A4. Therefore, dosage adjustments are necessary when this medication is given with other medications that either inhibit or induce these enzymes. For example, the dose of aripiprazole should be halved when this medication is given with ketoconazole, a CYP 3A4 inhibitor, or at least decreased when given with fluoxetine, a CYP 2D6 inhibitor. When aripiprazole is given with CYP 3A4 inducers such as carbamazepine, the dose should be doubled. 

When concomitant administration of ketoconazole with aripiprazole occurs, aripiprazole dose should be reduced to one-half of its normal dose. Other strong inhibitors of CYP3A4 (itraconazole) would be expected to have similar effects and need similar dose reductions weaker inhibitors (erythromycin, grapefruit juice ) have not been studied... 

ARIPIPRAZOLE ITRACONAZOLE, KETOCONAZOLE t aripiprazole levels Inhibition of metabolism L dose of aripiprazole... 

Modest elevations of aripiprazole serum concentration occur in the presence of ketoconazole or quinidine, which inhibit CYP 2D6 and 3A4, respectively. Carbamazepine has been reported to decrease aripiprazole serum concentrations. ... 

Anti-inflammatory drugs Ketoconazole decreases aripiprazole... 

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