Aripiprazole dosage

Sprinkle capsule 15, 25 mg Atypical Antipsychotics FDA approved for use in bipolar disorder Aripiprazole Abilify Tablets 5, 10, 15, Dosage should be slowly increased to minimize adverse effects (e.g., 25 mg at bedtime for 1 week, then 25-50 mg/day increments at weekly intervals) 10-30 mg/day once daily acute treatment of mania or mixed episodes due to lack of efficacy used as an adjunctive agent with established mood stabilizers Use as monotherapy or in... 

Aripiprazole is hepatically metabolized, mainly by two cytochrome P450 enzymes CYP 2D6 and CYP 3A4. Therefore, dosage adjustments are necessary when this medication is given with other medications that either inhibit or induce these enzymes. For example, the dose of aripiprazole should be halved when this medication is given with ketoconazole, a CYP 3A4 inhibitor, or at least decreased when given with fluoxetine, a CYP 2D6 inhibitor. When aripiprazole is given with CYP 3A4 inducers such as carbamazepine, the dose should be doubled. 

Generic Name Aripiprazole Trade Name Abilify Usual Dosage Range (mg/d) 10-30 Maximum recommended dosage (mg/d) 30... 

The manufacturers suggest that potent inhibitors of CYP2D6, such as fluoxetine and paroxetine would be expected to increase aripiprazole levels, and they recommend that the dose of aripiprazole should be halved if these drugs are given. The UK manufacturer suggests that weaker inhibitors of this isoenzyme (they name escitalopram) would only be expected to cause modest increases in aripiprazole levels, and therefore no dosage adjustment would expected to be required. ... 

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