Arguments against the Precommitment Hypothesis

Although the RNA transformation experiments are often considered to be arguments against the precommitment hypothesis, I believe that in fact they are irrelevant to the subject. First of all, it is not surprising that a cell equipped with a functional protein synthetic machinery would be able to translate RNA to protein if the former could enter the cell intact. It has recently been shown that RNA, injected into amphibian eggs, will be readily translated into myeloma polypeptide chain (Stevens and Williamson, 1972). I suggest the RNA transformation experiments should be disregarded in the present context as they probably do not reflect normal in vivo processes. 

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