Arginine residues lactate dehydrogenase

All malate dehydrogenases have an arginine residue at position 102, whereas most lactate dehydrogenases have a glutamine at this position. Mutation of Gin —> Arg-102 in lactate dehydrogenase increases the activity toward oxaloac-etate by a factor of 103 and decreases the activity toward pyruvate by 104 i.e., a... [Pg.245]

L-lactate dehydrogenase and, 269 small NADH dehydrogenase and, 199 succinate dehydrogenase and, 239, 250 ubiquinone reductase and, 182, 197 yeast NADH dehydrogenase and, 219 Antiparallel sheet, glyceraldehyde-3-phosphate dehydrogenase, 13, 14 Arginine residues catalase, 395... [Pg.437]

The chemical modifications of cysteine sulfhydryl, histidine imidazole and arginine residues in lactate dehydrogenase lead to a total loss of enzymatic... [Pg.226]