Arginase binuclearity

Arginase, 46 306-307 binuclearity, 46 325-327 EPR spectroscopy, 46 389 hydrogen peroxide disproportionation, 46 326-327... 

Kanyo ZF, Scolnick LR, Ash DE, Christianson DW. Structure of a unique binuclear manganese cluster in arginase. Nature 1996 383 554-7. 

Arginase A Binuclear Manganese Metalloenzyme David E. Ash, J. David Cox, and David Wi Christianson... 

These enzymes catalyze the hydrolysis of L-arginine to form L-ornithine and urea. Mammalian arginases have been divided into classes I and II as a function of their location arginase I is predominantly found in the liver whereas arginase II is located in non-hepatic tissues and functions primarily in L-arginine homeostasis [110]. The crystal structure of rat arginase I has shown the active site to be composed of a Mn binuclear center. The Mn(II) and Mn(II)g ions which are... 

Hies, M., Di Costanzo, L.D., North, M.L., Scott, J.A., and Christianson, D.W. (2010) 2-Aminoimidazole amino acids as inhibitors of the binuclear manganese metalloenzyme human arginase I. J. Med. Chem., 53, 4266A276. 

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