Ruthenium arene

Scheme 141 illustrates the preparation of related cationic Ti-arene ruthenium amidinates. ... 

An unprecedented carbene insertion reaction was observed on reaction of the cationic re-arene ruthenium amidinates with trimethylsilyldiazo-methane (Scheme 145, TFPB = tetrakis[3,5-bis(trifluoromethyl)phenyl]borate). 

Among the most active catalysts for the asymmetric transfer hydrogenation of prochiral ketones and imines to chiral alcohols and amines are arene-ruthenium(II) amino-alcohol (or primary/ secondary 1,2-diamine)-based systems, with an inorganic base as co-catalyst, developed by Noyori139-141 and further explored by others (Scheme 27).142-145... 

Self-assembled hexanuclear arene ruthenium metallo-prisms with 2,4,6-tripyridyl-l,3,5-triazine (ppt) subunits showed unexpected double helical chirality <06CC4691>. 

We reported the first crystal structure of a half-sandwich arene ruthenium(II)-enzyme complex (Fig. 21) (90). The crystal structure showed a Ru(r 6-p-cym)X2 half-sandwich fragment... 

An unexpected endo selectivity in addition of certain carbon and sulfur nucleophiles to the O, / -unsaturated (arene)ruthenium(II)cyclopentadienyl compound (154) has been reported. This stereochemistry has been compared with that of the 5 n2 reactions but a detailed theoretical approach is yet to be undertaken. ... 

Arene)ruthenium-indenylidene complex XV (Scheme 8.11), developed by Dixneuf et al. [33, 34] was also a very efficient catalyst for RCM of dienes and enyne metathesis (Table 8.4). 

An arene ruthenium complex with polymerizable side chains for the... 

AN ARENE RUTHENIUM COMPLEX WITH POLYMERIZABLE SIDE CHAINS FOR THE SYNTHESIS OF IMMOBILIZED CATALYSTS... 

Rich and co-workers employed the intramolecular SNAr reaction of arene-ruthenium n-complexes in their total syntheses of K-13 (9) and OF4949-III (7). Treatment of tripeptide complex 27 with potassium ferf-butoxide gave 17-membered macrocycle 28, which was demetalated in acetonitrile to give cycloisodityrosine 29, a precursor to OF4949-III (7) (Scheme 8). 34 ... 

In a reaction that similarly relies on the acidity of benzylic protons in arene-ruthenium(II) complexes, the r 6-mesitylene complex 92 containing bidentate (C6F5)2PCH2CH2P(C6F5)2 loses two molecules of HF on treatment with proton sponge to give the di-strapped salt 93 in which each tether contains three carbon atoms [Eq. (18)]).83... 

Petzold H, Xu J, Sadler PJ (2008) Metal and ligand control of sulfenate reactivity arene ruthenium thiolato-mono-S-oxides. Angew Chem Int Ed 47 3008-3011... 

Zobi F, Mood BB, Wood PA, Fabbiani FPA, Parsons S, Sadler PJ (2007) Tagging (arene) ruthenium(II) anticancer complexes with fluorescent labels. Eur J Inorg Chem 2783-2796... 

Therrien B (2009) Arene ruthenium cages boxes full of surprises. Eur J Inorg Chem 2445-2453... 

Schmitt F, Govindaswamy P, Zava O, Suss-Fink G, Juillerat-Jeanneret L, Therrien B (2009) Combined arene ruthenium porphyrins as chemotherapeutics and photosensitizers for cancer therapy. J Biol Inorg Chem 14 101-109... 

Auzias M, Therrien B, Siiss-Fink G, Stepnicka P, Ang WH, Dyson PJ (2008) Ferrocenoyl pyridine arene ruthenium complexes with anticancer properties synthesis, structure, electrochemistry, and cytotoxicity. Inorg Chem 47 578-583... 

In order to generate elongated structures, longer and more flexible spacers connecting two tri-functional ligands coordinated to six arene ruthenium units have been combined [37]. The (pPr CgH4Me)Ru 6(p-L3)2 (where L3 = 2,3-... 

Cationic metalla-assemblies have been prepared using the same dinuclear arene ruthenium clips and 5,15-bis(4-pyridyl)-10,20-diphenylporphyrin (bpp) or 5,10, 15-tris(4-pyridyl)-20-phenylporphyrin (tppp) instead of 5,10,15,20-tetra(4-pyridyl) porphyrin (tpp) (Fig. 15). The in vitro study showed that, despite having less ruthenium atoms per metalla-assemblies and a reduced overall charge as compared to the octanuclear arene ruthenium metalla-cubes, the cytotoxicity of these tetra-and hexanuclear metalla-assemblies was similar to those observed for the octanuclear metalla-cubes [55]. 

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