Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Arecaidine propargyl ester

FIGURE 7.7 Effect of the allosteric modulator ebumamonine on the potency of muscarinic agonists on m2 receptors. It can be seen that while no change in potency is observed for APE (arecaidine propargyl ester) pilocarpine is antagonized and arecoline is potentiated, illustrating the probe dependence of allosterism. From [1],... [Pg.131]

Wolf-Pflugmann M, Lambrecht G, Wess J, Mutschler E. (1989). Synthesis and muscarinic activity of a series of tertiary and quaternary N-substituted guvacine esters structurally related to arecoline and arecaidine propargyl ester. Arzneimittelforschung. 39(5) 539-44. [Pg.468]

Recently, it was shown that arecaidine propargyl ester produces relaxation of aortic rings (with intact endothelium) by interaction with M3 receptors. Also in neuroblastoma... [Pg.779]

X glioma hybrid cells arecaidine propargyl ester is a partial agonist of M4 muscarinic receptors Thus, arecaidine propargyl ester seems to be a rather unselective muscarinic agonist. [Pg.780]

Arecaidine propargyl, 2-butynyl and 2-pentynyl esters caused dose-dependent tachycardia in the pithed rat. This activity was blocked by small doses of pirenzepine, indicating that it was mediated by Mi ganglionic receptors. ... [Pg.779]

The propargyl ester of a bridged derivative of arecaidine, in which there is even lesser conformational flexibility than in arecaidine, was found to be a competitive antagonist in the isolated guinea pig ileum and a partial agonist of cardiac M2 muscarinic receptors. ... [Pg.779]

See other pages where Arecaidine propargyl ester is mentioned: [Pg.131]    [Pg.2371]    [Pg.133]    [Pg.55]    [Pg.1173]    [Pg.1177]    [Pg.1178]    [Pg.740]    [Pg.779]    [Pg.779]    [Pg.779]    [Pg.2371]    [Pg.131]    [Pg.2371]    [Pg.133]    [Pg.55]    [Pg.1173]    [Pg.1177]    [Pg.1178]    [Pg.740]    [Pg.779]    [Pg.779]    [Pg.779]    [Pg.2371]    [Pg.62]    [Pg.68]    [Pg.76]   
See also in sourсe #XX -- [ Pg.55 , Pg.57 ]



SEARCH



Arecaidine

Propargylic esters

© 2024 chempedia.info