Archetypal Bacterial CYPs

CYP number Gene H37Rv CDC1441,2I0 M bovis M. avium M. smegmatis M. leprae 

Notes Also shown is whether a pseudogene for the M. tuberculosis CYP exists in M. leprae. ML0447 and ML2159 (M. leprae ORF identifier) are identical pseudogenes in M. leprae that resemble S. coelicolor A3(2) CYP102B1 and ML 2088 is the only putative functional CYP oY M. leprae where another member of this family is only found in M. smegmatis. The TIGR databases were utilized here. 

Other bacterial CYPs also undertake the breakdown of carbon sources for microbial growth. For instance, CYP 108A1 (P450 gjjp) metabolizes ter-pineol , and CYPl 76A1 (P450 j J can metabolize cineol, while others can metabolize pollutants such as thiocarbamate herbicides and atrazine, as illustrated by CYPl 16 from a Rhodococcus sp. °. The CYP 105 family of streptomycetes especially is associated with a wide variety of xenobiotic 

Besides being present in proteobacteria, CYPs are also present in archaebacteria and some of these, CYP119 from Sulfobolus solfataricus and CYP 175 from Thermus thermophilus, have had their structure solved While these are interesting, the absence of known endogenous function precludes their discussion here. Thermophilic CYPs have been studied and we await functions, as well as CYP stucture/fimction for CYPs with activity at low temperatures that may have industrial uses. 

---