Applications to the Synthesis of Biologically Active Products

SCHEME 17.25 Synthesis of (S)-bifonazole. (Ad ted with permission from Ref. [10]. Copyright (2009) American Chemical Society). 

4 CYCLOTRIMERIZATION FOR THE SYNTHESIS OF AROMATIC COMPOUNDS BY METATHETIC PROCESSES 

Transition metal-catalyzed cyclotiimerizations [48] are a very important method for the synthesis of polysubstituted aromatic systems [49]. In this section, we will illustrate the use of this methodology for the de novo construction of a benzene ring, although the final products produced in many cases may be considered to be heteroaromatic. 

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