Applications of ELSD

Low UV absorptivity is also true for the compound class of ginsenosides. These compounds are triterpenic (steroidal) saponins, which are considered to be the main bioactive constituents in Panax ginseng and a related species P. quinquefolius (American ginseng) with antistress, antihyperglycemic, and potential antitumor properties. There are seven major ginsenosides present in P. 

Because ginsenosides do not strongly absorb above 205 nm, HPLC methods based on low wavelength UV detection suffer from baseline noise and low sensitivity that limits the choice of solvents and mobile-phase additives for improved separation. With ELSD, interferences are reduced and baseline slopes are not as pronounced or as variable, maldng peak area determination more reliable [114,115]. 

A popular application for ELSD in the food and beverage industry is the analysis of carbohydrates in various matrices. In contrast to integrated pulsed amper-ometric detection of carbohydrates, which is highly specific and sensitive, ELSD is considered to be the prevailing detection technique if carbohydrates are present in larger concentrations. However, the main problem encountered in 

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