Applications of DCC in Biological Systems

For this reason, several reversible chemistries that are efficient in organic phase (e.g., catalyzed by acids or bases) are less convenient in aqueous media. Instead, reactions occurring under sufficiently mild conditions need to be employed. These restrictions have led to the preference of but a few different reaction types, and, to date, mainly imines (including hydrazones, oximes, etc.), disulfides, and metal coordination are employed in these systems. However, other reaction types, such as transthiolesterification, conjugate addition, aUcene metathesis, and aldol addi-tion/condensation, have been demonstrated, but are so far less preferred in these systems. 

Target Reversible chemistry Library size Hit(s) Reference 

AChE acyl hydrazone exchange 66 bis-pyridinium structure [24] 

HPr kinase/phosphatase acyl hydrazone exchange 440 2-aminobenzimidazole m 

Aurora kinase thiol-disulfide exchange ND 3 -amidobenzamide structure [29] 

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