Applications Angiogenesis

The growing list of endogenous inhibitors of angiogenesis holds great promise for therapeutic applications (Table 2). Substances most advanced in clinical development include Endostatin, Angiostatin, Interleukin-12, Thrombospondin, and Tumstatin. As... 

Folkman J. Seminars in medicine of the Beth Israel Hospital, Boston Clinical applications of research on angiogenesis. N Engl J Med 1995 333 1757-1763. 

The results by Hetrick et al.32 support the use of NO-release coatings for developing more tissue-compatible sensors. However, the impact of NO on the biocompatibility at a NO-releasing implant is a multifaceted question that is still not fully understood. Further study into the mechanisms by which NO decreases tissue encapsulation and chronic immune response while increasing angiogenesis will aid in optimization of the NO release properties (e.g., flux, concentration, and duration) of an implant coating for sensor applications. 

Vermette P, Meagher L, Gagnon E et al (2002) Immobilized liposome layers for drug delivery applications inhibition of angiogenesis. J Control Release 80 179-195... 

In patients with ischemic syndromes, intra-arterial administration of rhVEGF significantly increases the development of collateral vessels (Isner and Asahara 1999), indicating its applicability in therapeutic angiogenesis. In patients who are not suitable for PTCA or CABG, administration of VEGF can be a novel treatment option. 

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