Application to Viral and Immunodeficiency Diseases

To date, clinical studies have been carried out using small doses of ascorbate, whereas preliminary observations from noncontrolled studies suggest that large doses provided strong benefits. Large-scale trials are needed to demonstrate conclusively the value of megadoses of vitamin C in vivo. From a practical standpoint. 

Acknowledgments. The authors are most grateful to Martha Best for help in processing this manuscript. 

Anderson, R., 1981a, Ascorbic acid and immune functions Mechanism of immunostimulation, in Vitamin C (Ascorbic Acid) (J. N. Counsell and D. H. Homig, eds.), pp. 249-272, Applied Science, London. 

Anderson, R., 1981b, Assessment of oral ascorbate in three children with chronic granulomatous disease and defective neutrophil motility over a 2-year period, Clin. Exp. Immunol.43 S0. 

Anderson, R., Oosthuizen, R., Maritz, R., Theron, A., and Van Rensburg, A. J., 1980, The effects of increasing weekly doses of ascorbic acid on certain cellular and humoral immune functions in normal volunteers. Am. J. Clin. Nutr. 33 71. 

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