Application to transition path sampling

In this section, we will discuss two applications of parallel tempering in path ensemble simulations  

Simulation at different temperatures. When paths are sampled in the canonical ensemble, i.e. 

Umbrella sampling. To compute P (A,t), it is sometimes advantageous to define overlapping regions Bt by 

Of course, both techniques can also be combined to sample P (A,t, (3) for different overlapping regional B and different temperatures pt in a single simulation. 

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