Application strategies substituent choice

A variety of strategies have been developed for the synthesis of the isothiazole ring system, and the route selected will depend on the substituents required and the availability of starting materials. The most useful and general method remains the formation of the S—N bond by oxidative cycli-zation of a suitable S—C—C—C—N unit because such compounds are readily available. Depending on the choice of starting material the route is applicable to the synthesis of isothiazoles, isothiazolin-... 

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