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Application of Thermodynamic Solubility Data in LI and LO

In LI and LO, thermodynamic solubility data are used to aid the understanding of DMPK data and guide formulation. When solubility is low, DMPK issues arise, such [Pg.26]

1 Lipinski, C.A., Lombardo, F., Dominy, B.W. and Feeney, P.J. (2001) Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Advanced Drug Delivery Reviews, 46, 3-26. [Pg.28]

2 Kerns, E. (2001) High throughput physicochemical profiling for drug discovery. Journal of Pharmaceutical Sciences, 90 (11), 1838-1858. [Pg.28]

and Kerns, E.H. (2006) Biological assay challenges from compound solubility strategies for bioassay [Pg.28]

4 McGovern, S.L., Caselli, E., Grigorieff, N. and Shoichet, B.K. (2002) A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening. Journal of Medicinal Chemistry, 45, 1712-1722. [Pg.29]


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