Application of Optical Sensor for Pharmaceutical Drug Determination

3 Application of Optical Sensor for Pharmaceutical Drug Determination 

1 TEOS-Doped Nano-Optical Sensor for Pharmaceutical Determinations 

1 Determination ofRamipril by Using Sm -Doxycycline Doped in TEOS matrix 

Ramipril concentration was determined by the optical sensor Sm +-Doxycycline (Sm -DC) complex doped in the sol-gel matrix. The method depends on the quenching of the luminescence intensity of the optical sensor in the presence of different concentrations of Ramipril, especially at 645 nm band [55]. 

The mechanism depends on the energy transfer from excited energy state of Sm to the singlet excited state of the Ramipril. In comparison with other spectrofluo-rimetric techniques, this method is simple, relatively interference free from coexisting substances and can successfully be applied to the determination ofRamipril in pharmaceutical preparations and in serum samples with remarkably satisfactory results. The Ramipril was determined in each tablet (Corpril or Ramipril or Tritace) and serum samples data are summarized in Table 14.2. 

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