Application of Chiral Pincer Complexes

These studies show that variation of the steric bulkiness of the chiral ligands in the side arms strongly influences the selectivity of the cydization reactions. However, obtaining full control over both the stereo and enantioselectivity of the reaction is stiU very challenging. 

A particularly interesting feature of the above reaction is the change of the stereoselectivity of the process upon changing the heteroatoms of the side arms (Table 4.1). 

In case of PCP complexes la-d, a syn selectivity was obtained, while with a-donor groups in the side arms la-g, the stereoselectivity was reverted and decreased. 

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