Appetite loss intravenous

In a randomized, crossover study, 25 volunteers received single doses of intravenous mesna and four different formulations of oral mesna (1). One subject withdrew from the study because of ocular inflammation followed by loss of appetite, nausea, and vomiting. Another developed a rash during the period in which three of his four oral doses were given. Two further subjects developed loose stools after one of the oral doses. Another reported dizziness after an oral dose. One reported pain at the site of the intravenous infusion. The adverse effects were all considered to be mild or moderate and resolved spontaneously without treatment. 

Mice fed a "gross overdose" of ginkgo seed for 60 days were observed to have weight loss, poor appetite, liver damage, and glomerulonephritis, and some animals died. Intravenous administration of ginkgo seed extract caused an increase followed by a decrease in blood pressure, dyspnea, seizures, and death (Anonymous 1989, 1995). Decoctions of the seed are recognized as nontoxic (Bensky et al. 2004 Chen and Chen 2004). 

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