Appetite bioavailability

ITRACONAZOLE KETOCONAZOLE t itraconazole levels, with risk of toxic effects Ketoconazole is a potent inhibitor of the metabolism of itraconazole by the CYP3A4 and a potent inhibitor of P-gp, which is considered to T bioavailability of itraconazole Warn patients about toxic effects such as swelling around the ankles (peripheral oedema), shortness of breath, loss of appetite (anorexia) and yellow discoloration of the urine and eyes (jaundice), i dose if due to interaction... 

APPETITE SUPPRESSANT with low oral bioavailability, and is used as a pharmacological tool. 

Sesame oU solubilizes 2.5 mg, 5 mg or 10 mg dronabinol, also known as A-9-tetrahydrocannabinol, in Marinol soft gelatin capsules. Dronabinol is the principal psychoactive component of cannabis and hnds therapeutic application as an anti-emetic for treatment of the nausea and vomiting associated with cancer chemotherapy or as an appetite stimulant to treat AIDS wasting syndrome. Dronabinol exists as a hydrophobic oil at ambient room temperature, and after oral administration is almost completely absorbed (90-95%). However, the bioavailability of dronabinol is only about 10-20% due to extensive hepatic hrst-pass metabolism. The dose of dronabinol is 2.5-10 mg (one capsule) twice daily. Marinol soft gelatin capsules should be stored at 8-15° C and must be protected from freezing. Marinol is available in the USA. 

---