Apoptosis promotors

BID is a member oftheBcl-2 gene family, which encode proteins that function either to promote apoptosis or to inhibit apoptosis as in the proteins derived from Bcl-2. These proteins can exist as monomers or they can dimerize. For example, if two promoting Bcl-2 family proteins dimerize then apoptosis will be greatly enhanced. Conversely, if dimerization of an inhibitory and promotor protein occurs, then the effects are cancelled out. The Bcl-2 family of proteins are localized to the outer mitochondrial or outer nuclear membranes. 

Introduction Cyclooxygenase-2 Antiangiogenesis Agents Signal Transduction Inhibitors Ras Farnesylation Inhibitors Cell Cycle Inhibitors Promotors of Apoptosis Conclusions References... 

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