Apomorphine hormonal

Apomorphine stimulated growth hormone release via dopamine D2 receptors. [Pg.369]

C(t) modeled according to two-compartment model with zero-order and first-order absorption Pharmacokinetic/pharmacodynamic relationship modeled using Hill model with first-order absorption. Modeled parameters matched experimental parameters when bicompartmental model with zero-order input was used. Linear PKs, anticlockwise hysteresis loop established for all doses studied. Apomorphine and growth hormone concentration predicted with good accuracy... [Pg.369]

Aymard, G., Berlin, L, de Brettes, B., and Diquet, B., Pharmacokinetic-pharmacodynamic study of apomorphine s effect on growth hormone secretion in healthy subjects, Fundam. Clin. Pharmacol., 17, 473-481, 2003. [Pg.374]