Aplysinopsine synthesis

Alkyl 3-dimethyl-2-(177-indol-3-yl)propenoates have found an important role in the synthesis of 3-heteroarylindoles as part of a program aimed at the total synthesis of aplysinopsins and related cytotoxic compounds (Scheme 44)... 

The synthesis of aplysinopsins, meridianines, and related compounds of marine origin 05MRO211. 

Gulati, D Chauhan, P.M.S., Pratap, R., and Bhakuni, D.S. (1994) A new synthesis of aplysinopsin, a marine alkaloid and its analogues and their biological activities. Indian J. Chem. Sect. B, 33, 4-9. 

Selic, L., Jakse, R., Lampic, K., Golic, L, Gohc-Grdadolnik, S and Stanovnik, B. (2000) A simple stereoselective synthesis of aplysinopsin analogs. Hdv. Chim. Acta, 83, 2802-2811. 

Stanovnik, B. and Svete, J. (2005) The synthesis of aplysinopsins, meridianins, and related compounds. Mini-Rev. Otg. Chem., 2, 211-224. 

Reddy, Y.T., Reddy, P.N., Koduru, S., Damodaran, C., and Crooks, P.A. (2010) Aplysinopsin analogs Synthesis and anti-prohferative activity of substituted (2)-5-(N-ben2ylindol-3-yhnethylene)imidazolidine-2,4-diones. Bioorg. Med. Chem., 18, 3570-3574. 

Guella, G., Mancini, I., Zibrowius, H., and Pietra, F. (1988) Novel aplysinopsin-iype alkaloids from sderactmian corals of the family Dendrophylliidae of the Mediterranean and the Philippines. Confignrational-assignment criteria, stereospecific synthesis and photo-isomerisation. Hdv. Chim. Acta, 71, 773—781. 

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