APCI sulfonylureas

El.El. Maurer, C. Kratzsch, T. Kraemer, F.T. Peters, A.A. Weber, Screening, library-assisted identification and validated quantification of oral antidiabetics of the sulfonylurea-type in plasma by LC-APCI-MS, J. Chromatogr. B, 773 (2002) 63. 

Liquid chromatography-mass spectrometry The initial attempts to couple LC with MS lacked important attributes for trace analysis sensitivity, robustness, and reliable quantitation. Moreover, the cost of the early LC-MS instruments was prohibitive for most laboratories. The revolutionary introduction of atmospheric pressure ionization (API) techniques, mainly electrospray (ESI) and atmospheric pressure chemical ionization (APCI), resulted in greater applicability of LC-MS and manufacture of more reliable, affordable, and user-friendly instruments. Thus, LC-MS is now becoming an indispensable part of the analytical strategy in many routine laboratories, enabling direct, selective, and sensitive multiclass, multiresidue analysis of more polar, low volatile, and/or thermolabile pesticides, such as carbamates, phenylureas, sulfonylureas, imidazoles, triazoles, imidazolinones, chlorophenoxy acids, and many others. 

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