Antitumor tissue extracts

The results of an antitumor screen are summarized in Table 8.1. The attrition table summarizes the results from 338,072 samples tested against tumor cells derived from soft tissue sarcomas. Given that the samples included one combinatorial collection with approximately 1.5 million compounds and that each natural product extract most likely contained 100 or more, the total number of compounds tested in this screen exceeded 5 million. As shown in the first column of Table 8.1, the samples were from 11 collections composed of single synthetics, compounds synthesized by combinatorial chemistries, and purified natural products and extracts. The natural products were derived from microorganisms (actinomyces and fungi), plants, and marine invertebrates. 

Fig. (59). Antitumor effects of 5-Fu and 5-FU plus carp extract 5-FU or 5-FU plus carp extract were administered orally twice daily for 8 days. On day 9, blood and each tissues were obtained.

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