Antitumor Peptidomimetic

Cyclosporin (Section 16.1.3) is an undecapeptide that acts as a potent immunosuppressant. Seven of its eleven residues are N-methylated. Its synthesis in solution was carried out by a series of segment condensations)32,33 The didemnins (Section 16.1.4) are isolated from marine organisms known as tunicates. Their therapeutic potential lies in applications as antitumor, antiviral, and immunosuppressant agents. The didemnin family of natural products contains peptidomimetic residues including A,0-dimethyltyrosine-proline and leucine—2-(hydroxyisovaleryl)propionic acid and (4-hydroxy)-2,5-dimethyl-3-oxo-... 

Sun, J., Blaskovich, MA., Knowles, D., Qian, Y., Qhkanda, J., Bailey, R.D., Hamilton, A.D., and Sebti, S.M (1999). Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase 1 combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine. Cancer Res 59 4919-4926. 

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