Germanium antitumor activity

In contrast to their germanium analogues, the main applications of tin heterocycles are not concerned with their biological activity although several 1,3,2-dioxastannolane derivatives exhibit in vitro antitumor activity (88BSB873, 92H(34)549>. The two most important fields involve technical uses of 1,3,2-diheterastannolanes and their use in organic synthesis. 

Germanium and silicon derivatives of furfural semicarbazone and thiosemicarbazone exhibited similar antitumor activity to melanoma B16 in mice (40-48% inhibition of the growth)138. 

Silicon and germanium heterocycles, antitumor activity of 87-KFZ402. 

Some plants have been cultivated by germanium penetration into the plant from its roots and organogermanium pharmaceuticals have been prepared. Cultivation of Sac-charomyces cerevisiae or Ganoderma lucidum in carboxyethylgermanium sesquioxane medium gave a product with antitumor and interferon-inducting activity . 

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