Antiretrovirals acyclovir

The synthesis and biological activity of the new acyclic heterodinucleotide (113) that consists of both an antiherpetic (acyclovir) and an antiretroviral (2-(phosphonomethoxy)propyl-adenine) drug linked by a pyrophosphate bridge were reported. The heterodinucleotide (113), prepared from the reaction of a morpholidate derivative of PMPA and the tributylammonium salt of acyclovir monophosphate in the presence of pyridine, behaved as a pro-drug in macrophages. Anti-HIV and anti-HSV activity of this compound were demonstrated in HIV-lfia-L and HSV-1-infected macrophages. ... 

Items 92-93. A 30-year-old hospitalized AIDS patient has a CD4 cell count of 50/ tL. He is being treated with a highly active antiretroviral therapy (HAART) regimen consisting of zidovudine (ZDV), lamivudine (3TC), and indinavir. Other drugs being administered to this patient include acyclovir, clarithromycin, foscamet, rifabutin, and trimethoprim-sulfamethoxazole. 

The 19-year-old client diagnosed with a severe herpes simplex 2 viral infection is admitted to the medical floor. The HCP prescribes acyclovir (Zovirax), an antiretroviral medication, 10 mg/kg IVPB every 8 hours. The client weighs 220 pounds. How many milligrams will the nurse administer with each dose ... 

Antiretroviral agents Acyclovir, adefovir, tenofovir, indinavir Acute interstitial nephritis, tubular cell toxicity... 

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