Antipsychotics relative side effect profiles

B.l Common antipsychotics - approximate relative side effect profiles Appendix C Alcohol and drugs Appendix D Cognitive testing Appendix E Mental health legislation Appendix F Useful contacts Index... 

See Appendix B(l-3) for relative side effect profiles and specific antipsychotic information. 

B.l Common antipsychotics - approximate relative side effect profiles... 

It is thought that 5-HT2a antagonism together with relatively weaker dopamine antagonism are principal features that differentiate the side-effect profile of atypical antipsychotic agents of the first generation treatments. 

Contrary to the usual activity of antipsychotics, clozapine exhibits regional specific anti-dopaminergic profile having, relatively mild antagonism on the extrapyramidal dopaminergic action and this could be responsible for its low propensity to produce extrapyramidal side effects e.g., dystonias, tardive dyskinesia. It also causes greater blockade of dopamine D-1 receptors and however, it is not yet established whether such action precisely contributes to its antipsychotic therapeutic activity. 

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