Antioxidant defense mechanism

Chow, C. K., ed. (1988) Cellular Antioxidant Defense Mechanisms, CRC Press, Boca Raton, Florida (3 volumes)... 

K10. Komosinska-Vassev, K., Olczyk, K., Kucharz, E. J., Marcisz, C., Winsz-Szczotka, K., and Kotulska, A., Free radical activity and antioxidant defense mechanisms in patients with hyperthyroidism due to Graves disease during therapy. Clin. Chim. Acta 300, 107—117 (2000). 

Patel JM, Block ER. 1985. Cyclophosphamide-induced depression of the antioxidant defense mechanisms of the lung. Exp Lung Res 8 153-165. 

Prejbeanu, I., Pisoschi, C., Rada, C., Stanciulescu, C., Purcaru, O., Puiu, I. andTache, D. 2008. Nitrate exposure via groundwater pollution and its influence on the antioxidant defense mechanisms. Proceedings of the International Conference Environmental Pollution and its Impact on Public Health, organized by the Balkan Environmental Association, the 16th-18th July, Brasov, Romania. 

Ardelt, B.K., Borowitz, J.L., Isom, G.E. (1989). Brain lipid peroxidation and antioxidant defense mechanisms following acute cyanide intoxication. Toxicology 56 147-54. 

Ho, Y Wayne State University, Detroit, Ml The nature of lung antioxidant defense mechanisms NHLBI... 

Reactive aldehydes generated from hpid peroxidation are involved in CVD (266). Another example lies with the role of oxidative stress in the pathophysiology of asthma (267). Lipid peroxidation, as determined by plasma iso-prostanes, is related to disease severity in mild asthma. Tumor cell lines are sensitive to PUFA and to associated oxidation products (268). This sensitivity depends on the antioxidant defense mechanism, as well as on culture conditions. Hydroperoxy docosahexaenoic acid is a major metabolite, responsible for the cytotoxicity of DHA. 

Reiter RJ. 1995. Oxidative processes and antioxidative defense mechanisms in the aging brain. FASEB J 9 526-533. 

Abstract Low molecular weight antioxidants are an important part of the antioxidative defense mechanisms of cells and organisms. This chapter gives a short overview of the actions of the main antioxidants, including uric acid, ubichinones,lipoic acid, vitamins C and E, carotenoids, and phenolic compounds. The antioxidative properties of these endogeous and nutritional compounds are discussed in this chapter. However, it is critically discussed whether the antioxidative properties of some of these compounds are really important in vivo. 

Under normal circumstances, cellular antioxidant defense mechanisms minimize any damage. ROS are also formed during nonenzymatic processes. For example, exposure to UV light and ionizing radiation cause ROS formation. 

To protect themselves from oxidative stress, living organisms have developed several antioxidant defense mechanisms. These mechanisms employ several metalloenzymes and antioxidant molecules. 

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