Antinucleation effect

Another type of remarkable double crystalline materials that have been synthesized and characterized by Balsamo et al. are ABC triblock terpolymers composed of polystyrene, polyethylene and poly(ir-caprolactone) (PS-5-PE-6-PCL or SEC) [51-54,57,63]. The morphology, nucleation and crystallization of such copolymers have been recently reviewed [3]. It is interesting to mention that in such terpolymers the PE block induces an antinucleation effect [3,63] on its covalently bonded neighboring PCL block, a remarkable effect that has only been observed in this tjq >e of triblock terpolymer. Diblock copolymers or triblock terpolymers with two crystallizing blocks can display aU possible effects from the nucleation point of view of one crystallizing block on the other. One block can cause nucleation of the other, or cause no effect, or in the other extreme of behavior induce antinucleation. In addition to the... 

Balsamo V, Muller AJ, Stadler R (1998) Antinucleation effect of the polyethylene block on the polycaprolactone block in ABC triblock copolymers. Macromolecules 31(22) 7756-7763 Balsamo V, de Navarro CU, Gil G (2003) Microphase separation vs crystallization in polystyrene-b-polybutadiene-b-poly(epsilon-caprolactone) ABC triblock copolymers. Macromolecules 36... 

Polymer as a antinucleation agent A polymer can inhibit nucleation and crystal growth of a drug by specific interaction with functional groups of the drug (Curatolo et al. 2009 Alonzo et al. 2010). Polymers such as PVP, HPMC and HPMC-AS have been extensively studied for the amorphous stabilization effect in aqueous solution (Lindfors et al. 2008 Miller et al. 2008 Alonzo et al. 2010). 

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