Antimycotics azole fungicides

Figure 11. First azole antimycotics and fungicides developed for practical use. (Reproduced with permission from Ref. 9. Copyright 1983 Pergamon Press.)...

Figure 15. Azole fungicides and antimycotics from other subgroups.

In each data sheet, the core of information is the identification of substructural modification patterns which could be utilized as possible "rules" for the bioisosteric transformation in the lead evolution phase of the dnig design research not only within a single series, but also extended into other categories of bioactive compounds. There are numerous examples in which the structural evolution has occurred from agrochemicals to medicines (an example is the azole-type antimycotics shown in Fig. 1), from herbicides to fungicides as well as to insecticides and vice versa (Fujita, T. In Trends in QSAR and... 

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