Antimuscarinic agents contraindications

Buscopan is a branded preparation containing hyoscine butylbromide, an antimuscarinic agent that reduces gastrointestinal motility. Antimuscarinic agents are contraindicated in cases of angle-closure glaucoma as they may aggrevate the condition. Hyoscine butylbromide is a quaternary ammonium compound, unlike atropine, which is a tertiary ammonium compound. 

F. Contraindications The antimuscarinic agents should be used cautiously in infants because of the danger of hyperthermia. The drugs are relatively contraindicated in persons with glaucoma, especially the closed-angle form, and in men with prostatic hyperplasia. 

Carbocisteine is a mucolytic agent that may be used in chesty cough. Antihistamines tend to have antimuscarinic properties, resulting in urinary retention and are therefore contraindicated in prostatic hypertrophy. 

Kaolin/pectin is an antidiarrheal combination that absorbs fluid, and binds and removes digestive tract irritants. They are used for symptomatic treattnent of diarrhea. Kaopectate (190 mg kaolin/mL and 4.34 mg pectin/mL) is an antidiarrheal agent. By being absorbent, it recovers excess fluid in bowel dysfunction. It is contraindicated in obstructive bowel dysfunction. When used concomitantly, kaolin/pectin may impair absorption of the following drugs antidyski-netics, antimuscarinics (especially atropine), chloroquine. 

---