Antimicrobial Antineoplastics

PI Thrum, H. Haupt, I. Bradler, G. Zimmer, C. Reinert, K. E., In Advances in Antimicrobial Antineoplastic Chemotherapy, University Park Press Baltimore, MD, (1972) p 819. 

The mean uses per compound in Table V is 1.7. The mean uses per compound can be counted tor each ot the uses, it was shown (9) that mean uses per compound is distributed statistically and the outliers on each side could be identified. The ones with low mean uses per compound were highly specific uses such as antimicrobial, antineoplastics, antihistaminics, estrogenics, etc. The ones with high mean uses were the ones which were present in dominant use pairs or clusters such as diuretics, vasodilator, CNS depressant, etc., or which had old imprecise use descriptors such as sudorific, diaphoretic, dermatoses, etc. 

Despite fhe problems, however, some of the natural preparations were effective in relieving fhe symptoms and at times even eliminating the disease. In fact, we know today fhat fhe number of pharmacologically active substances produced by nature is large and fhe spectrum of biological activities of natural products is extraordinarily broad for example, antimicrobial, antineoplastic, CNS-active, anti-inflammatory, cardiovascular, etc., are only a few of the therapeutic classes of drugs from nature [7]. 

Thomson AJ, Mansy S. In Advances in Antimicrobial and Antineoplastic Chemotherapy Vol. IIL 1972 Baltimore University Press Baltimore, pp. 199-203. 

Figure 1.4 Percentage of drugs that have been prescribed in the United States for 2003-2005 as a fraction of the top 200 most prescribed drugs. Note that the total of the top 200 most prescribed was 2.1 bilhon, 2.8 biUion, and 2.3 billion for 2003, 2004 and 2005, respectively. AC = Antihypertension/cardiovascular medication, SH = sedatives/antipsychotics, AI = analgesics/anti-inflammatory, AM = antimicrobial, GI = gastrointestinal, AD = antidiabetic, DE = diuretics/electrol3ftes, TH = thyroid drugs. Re = respiratory, CR = contraceptives/ reproductive therapy, BP = biophosphonates and other anti-bone loss, St = steroids. He = hematology, Nu = nutritional, Tr = triptan, AP = antineoplast, AN = anesthetic, and DI = dopaminergics and immunomodulators.

Figure 2.11 Reported concentrations of various PPCPs in treated potable water by several research groups. So far reported are the analgesic (1 = naproxen), antihypertensive (2 = clofibric acid, 3 = dehydronifedipine, 4 = gemfibrozil), reproductive (5 = ethinyl estradiol, 6 = nor-ethindrone), antineoplasts (7 = metyhotrexate, 8 = bleomycin), sedatives (9 = carbamazepine, 10 = diazepam), and antimicrobials (11 = penicillin). Concentrations compiled from Boyd et al. (2003) and Collier (2007).

Pokeweed has various traditional uses, from medicinal to industrial processes. It is used as a cathartic, emetic, narcotic, and gargle. Additional medicinal uses include treatment of various skin diseases, conjunctivitis, syphilis, cancer, parasitic infestations of the scalp, chronic rheumatism, ringworm, dyspepsia, swollen glands, scabies, ulcers, edema, dysmenorrhea, mumps, and tonsillitis. It is currently popular for its antimicrobial and antineoplastic activity. 

Hodgson, L. M., Antimicrobial and antineoplastic activity in some south Florida seaweeds, Bot. Mar., 27, 387, 1984. 

Table 1 lists the MAO inhibitors that are already available or under investigation. These compounds fall into different chemical categories, including compounds that have the following properties antidepressant (moclobemide), antihypertensive (pargyline), antineoplastic (procarbazine), and antimicrobial (furazolidone). 

Pseudomembranous colitis was known before the introduction of antimicrobial agents and can still occur without previous antibiotic use, for example after antineoplastic chemotherapy (125) or even spontaneously. However, the number of cases has increased dramatically since antibiotics began to be used (126). Patients treated with lincomycin or clindamycin, cephalosporins, penicillinase-resistant penicillins, or combinations of several antibiotics... 

Hoigne R, Klein U, Muller U. Results of four-week course of therapy of urinary tract infections a comparative study using trimethoprim with sulfamethoxazole (Bactrim Roche) and trimethoprim alone In Hejzlar M, Semonsky M, Masak S, editors. Advances in Antimicrobial and Antineoplastic Chemotherapy. Munchen-Berhu-Wien Urban and Schwatzenberg, 1972 1283. 

Connors, T. A. Proc. VHth International Congress of Chemotherapy. In Adv. Antimicrobial and Antineoplastic Chemotherapy 2, 237 (1972). 

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