Antimicrobial and Antituberculosis Activity

Manzamine M, 3,4-dihydromanzamine J, and 3,4-dihydro-6-hydroxy-manzamine A showed antibacterial activity against S arcina lutea with MIC values of 2.3,12.5, and 6.3 mg/mL, respectively, and against Corynebacterium xerosis with MIC values of 5.7, 

1mg/mL, respectively. 32,33-Dihydro-31-hydroxymanzamine A, 32,33-dihydro-6,31-dihydroxymanzamine A, and 32,33-dihydro-6-hydroxymanzamine A-35-one were not active against cMoroquine-sensitive and -resistant strains of P. falciparum [49]. Ingenamine G exhibited antibacterial activity against S. aureus at 105 xg/mL, Escherichia coli at 75 p,g/mL, and four oxadllin-resistant S. aureus strains, two at concentrations between 10 and 50 p,g/mL, as well as antimycobacterial activity against M. tuberculosis H37Rv at 8.0p,g/mL [58]. 

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