Antimalarial activity, kalihinols

Miyaoka H, Shimomura M, Kimura H, Yamada Y (1998) Antimalarial Activity of Kalihinol A and New Relative Diterpenoids from the Okinawan Sponge, Acanthella sp. Tetrahedron 54 13467... 

Kalihinol A (108) was originally isolated as an antimicrobial compound from Acanthella sp. collected in Guam. Kalihinol A, and other isocyanides, including kalihinenes X (166), Y (167), and Z (168), as well as 10-formamidokalihinene (169) — all of which were isolated from the Japanese Acanthella cavernosa—were shown to inhibit the larval settiement and metamorphosis at concentrations less than 0.1 pgmP whereas toxicity toward the barnacle cyprids was very low (LD50 values > lOOpgmP ). Antimalarial activity was also reported for other biological activities of kalihinol A. ... 

Miyaoka, H., Shimomura, M., Kimura, H., Yamada, Y, Kim, H.S., and Wataya, Y. (1998) Antimalarial activity of kalihinol A and new relative diterpenoids from the Okinawan sponge, Acanthdla sp. Tetrahedron, 54, 13467-13474. 

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