Antilipaemic activity

There is a marked decrease or clearing of lipaemia when these compounds are injected into lipaemic subjects. This is readily demonstrated 

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Heparins and heparinoids are grouped in Table 3.2. Some are naturally occurring compounds, whilst others are derivatives prepared from heparins or from mucopolysaccharides. Semi-synthetic compounds have been prepared by degradation of natural polysaccharides followed by sulphation with chlorsulphonic acid or methyl sulphate . The common activities shown by the heparins and heparinoids—complexing with organic bases and proteins, antilipaemic activity and anticoagulant activity—are also shown by various sulphonic acid dyes and by polyphosphates. The table is completed with a list of those preparations that have been issued to provide depot preparations of heparins and heparinoids. 

When the responses are compared for two heparins and the heparinoids, it can be seen that the two heparins gave the same antilipaemic response, while the whale heparin gives twice the anticoagulant response of beef heparin. The response with the heparinoid is slower but greater and more prolonged for antilipaemic activity than heparin, while the reverse was the... 

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