Antiketogenesis Theory

On the other hand, there are a number of experiments which indicate that a relationship must exist between the oxidation of the ketone bodies and sugar these cannot be explained on the antiketogenesis theory. The strongest in vitro proof was originally demonstrated by Shaffer178 and has since been extended by West.179 180... 

Further evidence is afforded by the in vivo experiments where it has been shown that only D-glucose and D-glucose-precursors are able to lower ketonuria. According to the antiketogenesis theory, any readily metabolizable sources of calories should be able to suppress the oxidation of an isodynamic quantity of fat and so prevent the formation of the... 

These data on fasting ketonuria in man as well as the earlier described tests on the exogenous and endogenous ketonuria of rats indicate that marked changes in ketonuria can occur after the administration of carbohydrate in quantities too small to decrease significantly the fat catabolism. It is difficult to harmonize such results with the antiketogenesis theory. 

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