Antiinflammatory drugs, adverse drug reaction

Benoral benorylate. benorilate benorylate. benorylate [ban] (benorilate [inn] paracetamol acetylsallcylate BenoraP ) is an aspirin-paracetamol ester, and these two pharmacologically active constituents are released systemically at different rates. It has cyclooxygenase inhibitor, nsaid analgesic, antiinflammatory and antirheumatic activity. It is used orally, particularly to treat the pain of rheumatic disease and other musculoskeletal disorders, as well as to treat fever, benoxaprofen [ban, inn, usan] (Opren ) is one of the propionic acid series of CYCLOOXYGENASE INHIBITORS with nsaid ANALGESIC. ANTIINFLAMMATORY and ANTIPYRETIC activity also effective for psoriasis. It was withdrawn due to adverse drug reactions. 

The fenamates show no clear superiority in antiinflammatory activity and may produce more adverse effects than other NSAIDs. Diarrhea may be severe enough to necessitate discontinuation of drug use. Other adverse GI reactions include nausea, vomiting,... 

O Brien WM, Bagby GF. Rare adverse reactions to nonsteroidal antiinflammatory drugs. J Rheumatol 1985 12(l) 13-20. 

Bailey RR. Adverse renal reactions to non-steroidal antiinflammatory drugs and potassium-sparing diuretics. Adv Drug React Bull 1988 131 492. 

Weber JCP. 1984. Epidemiology of adverse reactions to non-steroidal antiinflammatory drugs. In Advances in Inflammation Research, vol. 6, Rainsford KD, Velo EP (eds). Raven New York 1-7. 

Stem, R.S. and Bigby M., An expanded profile of cutaneous reactions to nonsteroidal antiinflammatory dmgs reports to a specialty-based system for spontaneous reporting of adverse reactions to drugs, JAMA, 252,1433-1437,1984. 

The arylpropionic acid derivatives are useful for the treatment of rheumatoid arthritis and osteoarthritis, for reduction of mild to moderate pain and fever, and for pain associated with dysmenorrhea. Side effects of the drugs are similar to but less severe than those described for the salicylates. Those who are sensitive to salicylates also may be sensitive to and have adverse reactions when taking ibuprofen and related drugs. Acute hypersensitivity to ibuprofen has been reported in patients with lupus. The hypersensitivity reaction to sulindac can be fatal. The use of sulindac has also been linked to cases of acute pancreatitis. The use of dimethylsulfoxide (DMSO) topically in combination with sulindac has been reported to induce severe neuropathies. The concurrent use of ibuprofen with aspirin reduces the antiinflammatory effects of both drugs. Ibuprofen is contraindicated in patients with aspirin sensitivity leading to bronchiolar constriction and in patients with an-gioedema. As with all NSAIDs, renal and liver function should be normal for adequate clearance of the drugs. 

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